Nephro Trial Files Throwback Thursday: RRT Intensity in ATN, ARBs in Diabetic Nephropathy, and ARB vs. B-Blocker in HTN with LVH
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Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury VA/NIH Acute Renal Failure Trial Network. NEJM (July 2008) Bottom Line: This randomized controlled trial aimed to determine the optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury. 1124 patients were randomly assigned to receive either intensive or less-intensive therapy. The primary outcome was death from any cause by day 60. Both groups received intermittent hemodialysis, with the intensive group also receiving sustained low-efficiency dialysis six times per week and continuous venovenous hemodiafiltration at a higher dose. The results showed no significant difference in mortality between the two groups. However, more patients in the intensive therapy group experienced hypotension during intermittent dialysis. In conclusion, intensive renal support did not provide any significant benefit compared to less-intensive therapy in this patient population.
Nephro Trial Files Throwback Thursday: RRT Intensity in ATN, ARBs in Diabetic Nephropathy, and ARB vs. B-Blocker in HTN with LVH
Nephro Trial Files Throwback Thursday: RRT…
Nephro Trial Files Throwback Thursday: RRT Intensity in ATN, ARBs in Diabetic Nephropathy, and ARB vs. B-Blocker in HTN with LVH
Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury VA/NIH Acute Renal Failure Trial Network. NEJM (July 2008) Bottom Line: This randomized controlled trial aimed to determine the optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury. 1124 patients were randomly assigned to receive either intensive or less-intensive therapy. The primary outcome was death from any cause by day 60. Both groups received intermittent hemodialysis, with the intensive group also receiving sustained low-efficiency dialysis six times per week and continuous venovenous hemodiafiltration at a higher dose. The results showed no significant difference in mortality between the two groups. However, more patients in the intensive therapy group experienced hypotension during intermittent dialysis. In conclusion, intensive renal support did not provide any significant benefit compared to less-intensive therapy in this patient population.