Nephro Trial Files Throwback Thursday: Early vs. Late RRT in Severe AKI in ICU, Early vs. Late Dialysis in CKD, and Cinacalcet in ESRD
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Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit Gaudry S et al. NEJM (July 2016) Bottom Line: This multicenter randomized trial aimed to compare the effects of an early versus delayed strategy for renal-replacement therapy in critically ill patients with severe acute kidney injury. The study included 620 patients and the primary outcome was overall survival at day 60. Results showed no significant difference in mortality between the two strategies, but a delayed strategy may prevent the need for renal-replacement therapy in some patients. The delayed strategy also had a lower rate of catheter-related bloodstream infections and improved kidney function. This study provides evidence for the use of a delayed strategy in this patient population.
Nephro Trial Files Throwback Thursday: Early vs. Late RRT in Severe AKI in ICU, Early vs. Late Dialysis in CKD, and Cinacalcet in ESRD
Nephro Trial Files Throwback Thursday: Early…
Nephro Trial Files Throwback Thursday: Early vs. Late RRT in Severe AKI in ICU, Early vs. Late Dialysis in CKD, and Cinacalcet in ESRD
Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit Gaudry S et al. NEJM (July 2016) Bottom Line: This multicenter randomized trial aimed to compare the effects of an early versus delayed strategy for renal-replacement therapy in critically ill patients with severe acute kidney injury. The study included 620 patients and the primary outcome was overall survival at day 60. Results showed no significant difference in mortality between the two strategies, but a delayed strategy may prevent the need for renal-replacement therapy in some patients. The delayed strategy also had a lower rate of catheter-related bloodstream infections and improved kidney function. This study provides evidence for the use of a delayed strategy in this patient population.