Nephro Trial Files Throwback Thursday: Early vs. Delayed RRT in Septic Shock, Benazepril in Non-Diabetic CKD, and Immunosuppression after Kidney Transplant
Nephro Trial Files Throwback Thursday: Early vs. Delayed RRT in Septic Shock, Benazepril in Non-Diabetic CKD, and Immunosuppression after Kidney Transplant
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Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis Barbar SD et al. NEJM (October 2018) Bottom Line: This multicenter, randomized, controlled trial aimed to determine the ideal time for initiation of renal-replacement therapy in patients with early-stage septic shock and severe acute kidney injury. The study was stopped early for futility after the second planned interim analysis. A total of 488 patients were randomized to receive either early or delayed initiation of renal-replacement therapy. The primary outcome of death at 90 days showed no significant difference between the two groups. There were also no significant differences in life-threatening complications related to acute kidney injury. Overall, the study concluded that there was no significant difference in mortality at 90 days between patients who received early or delayed initiation of renal-replacement therapy.
Nephro Trial Files Throwback Thursday: Early vs. Delayed RRT in Septic Shock, Benazepril in Non-Diabetic CKD, and Immunosuppression after Kidney Transplant
Nephro Trial Files Throwback Thursday: Early…
Nephro Trial Files Throwback Thursday: Early vs. Delayed RRT in Septic Shock, Benazepril in Non-Diabetic CKD, and Immunosuppression after Kidney Transplant
Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis Barbar SD et al. NEJM (October 2018) Bottom Line: This multicenter, randomized, controlled trial aimed to determine the ideal time for initiation of renal-replacement therapy in patients with early-stage septic shock and severe acute kidney injury. The study was stopped early for futility after the second planned interim analysis. A total of 488 patients were randomized to receive either early or delayed initiation of renal-replacement therapy. The primary outcome of death at 90 days showed no significant difference between the two groups. There were also no significant differences in life-threatening complications related to acute kidney injury. Overall, the study concluded that there was no significant difference in mortality at 90 days between patients who received early or delayed initiation of renal-replacement therapy.