Nephro Trial Files: Prednisolone vs. Levamisole in Nephrotic Syndrome, Parathyroidectomy vs. Oral Cinacalcet for Kidney Failure and SHPT, and a Personalized Algorithm vs. Usual Care for CKD
Nephro Trial Files: Prednisolone vs. Levamisole in Nephrotic Syndrome, Parathyroidectomy vs. Oral Cinacalcet for Kidney Failure and SHPT, and a Personalized Algorithm vs. Usual Care for CKD
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An open label non-inferiority randomized controlled trial evaluated alternate day prednisolone given daily during infections vs. levamisole in frequently relapsing nephrotic syndrome Sinha A et al. Kidney International (May 2024) Bottom Line: This open label, non-inferiority trial compared the effectiveness of prednisolone and levamisole in preventing frequent relapses of nephrotic syndrome in children aged 2 to 18. The study included 160 patients and the primary outcome was the proportion of patients with frequent relapses. Results showed that while prednisolone was not non-inferior to levamisole in preventing frequent relapses, both therapies were effective in other outcome measures. Levamisole was also found to be relatively steroid-sparing and may be preferred in patients at risk of steroid toxicity.
Nephro Trial Files: Prednisolone vs. Levamisole in Nephrotic Syndrome, Parathyroidectomy vs. Oral Cinacalcet for Kidney Failure and SHPT, and a Personalized Algorithm vs. Usual Care for CKD
Nephro Trial Files: Prednisolone vs…
Nephro Trial Files: Prednisolone vs. Levamisole in Nephrotic Syndrome, Parathyroidectomy vs. Oral Cinacalcet for Kidney Failure and SHPT, and a Personalized Algorithm vs. Usual Care for CKD
An open label non-inferiority randomized controlled trial evaluated alternate day prednisolone given daily during infections vs. levamisole in frequently relapsing nephrotic syndrome Sinha A et al. Kidney International (May 2024) Bottom Line: This open label, non-inferiority trial compared the effectiveness of prednisolone and levamisole in preventing frequent relapses of nephrotic syndrome in children aged 2 to 18. The study included 160 patients and the primary outcome was the proportion of patients with frequent relapses. Results showed that while prednisolone was not non-inferior to levamisole in preventing frequent relapses, both therapies were effective in other outcome measures. Levamisole was also found to be relatively steroid-sparing and may be preferred in patients at risk of steroid toxicity.